INFLUENCE OF PEPTIDE COMPLEXES FROM KIDNEYS AND THYMUS ON DEXAMETHASONE- AND IONOPHORE-INDUCED APOPTOSIS IN THYMOCYTES AND PERIPHERAL BLOOD LYMPHOCYTES

Noginova O.A., Riabenko V.V., Kaidashev I.P.

On the basis of combined morphological, immunocytochemical and electrophoretic study the patterns of dexamethasone- and ionophore A23187-induced apoptosis in thymocytes and peripheral blood lymphocytes (PBL) were analyzed. PBL have been shown to be less susceptible to those agents than thymocytes. Incubation of dexamethasone- and ionophore-treated cells with peptide complexes from kidney or thymus resulted in decrease of their susceptibility to the apoptosis-inducing agents.