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ALTERATIONS OF MYC FAMILY GENES INDUCED BY ETOPOSIDE IN B- AND T- MALIGNANT LYMPHOID HUMAN CELLS
Gene structure alterations upon treatment of cells with anticancer drugs could be useful markers of drug susceptibility. Alterations of MYC-family (C-MYC and L-MYC) genes in transplantable B and T lines of malignant lymphoid cells treated with various doses of etoposide have been studied by Southern blot hybridization. The subtoxic doses of etoposide (0.4–2 mM) have been shown to induce substantial structural alterations of the genes under study in Namalwa and MT-4 cells upon prolonged incubation with the drug. Such alterations have been represented as rearrangements and deletions of certain gene fragments. The alteration revealed are supposed to be associated with the secondary leukemogenic effects of etoposide observed upon cancer treatment with this drug.
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