ATYPICAL BRAF MUTATIONS IN HAIRY CELL LEUKEMIA: DIAGNOSTIC AND THERAPEUTIC CONSIDERATIONS

Authors

  • S.E. LANGABEER Cancer Molecular Diagnostics, Trinity Translational Medicine Institute, St. James’s Hospital, Dublin, Ireland
  • G. CROTTY Department of Haematology, Midlands Regional Hospital, Tullamore, Ireland
  • C.L. BACON Department of Haematology, St. James’s Hospital, Dublin, Ireland

DOI:

https://doi.org/10.15407/exp-oncology.2025.01.122

Abstract

Atypical BRAF Mutations in Hairy Cell Leukemia: Diagnostic and Therapeutic Considerations

References

Falini B, Tiacci E. Hairy-cell leukemia. N Engl J Med. 2024;391(14):1328-1341. https://doi.org/10.1056/NEJM- ra2406376

Robak T, Robak P. Refractory and relapsed hairy-cell leukemia (HCL): casting light on promising experimental drugs in clinical trials. Expert Opin Investig Drugs. 2023;32(4):311-324. https://doi.org/10.1080/13543784.2023.2193323

Maitre E, Macro M, Troussard X. Hairy cell leukaemia with unusual BRAF mutations. J Cell Mol Med. 2023;27(17):2626- 2630. https://doi.org/10.1111/jcmm.17890

Langabeer SE, O’Brien D, McElligott AM, et al. BRAF V600E-negative hairy cell leukemia. Case Rep Hematol. 2013;2013:513049. https://doi.org/10.1155/2013/513049

Wang W, Lian B, Xu C, et al. Expert consensus on the diagnosis and treatment of solid tumours with BRAF muta- tions. Innovation (Camb). 2024;5(6):100661. https://doi.org/10.1016/j.xinn.2024.100661

So CC, Chan A, Chung LP, et al. A comparison of high resolution melting, allele-specific priming and Sanger se- quencing for the detection of BRAF V600E mutation in hairy cell leukaemia from different haematological speci- mens. Pathology. 2014;46(6):533-537. https://doi.org/10.1097/PAT. 0000000000000151

Broccoli A, Terragna C, Nanni L, et al. Droplet digital polymerase chain reaction for the assessment of disease bur- den in hairy cell leukemia. Hematol Oncol. 2022;40(1):57-62. https://doi.org/10.1002/hon.2932

Downloads

Published

11.07.2025

How to Cite

LANGABEER, S., CROTTY, G., & BACON, C. (2025). ATYPICAL BRAF MUTATIONS IN HAIRY CELL LEUKEMIA: DIAGNOSTIC AND THERAPEUTIC CONSIDERATIONS. Experimental Oncology, 47(1), 122–123. https://doi.org/10.15407/exp-oncology.2025.01.122

Issue

Vol. 47 No. 1 (2025): Experimental Oncology

Section

Letter to editor

License

Copyright (c) 2025 Experimental Oncology

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.