APPENDICULAR MUCINOUS CYSTADENOMA AND CYSTOADENOSARCOMA IN GYNECOLOGICAL PRACTICE. CLINICAL CASES AND LITERATURE REVIEW

Authors

  • V.О. SKLYAROVА Danylo Halytskyi National Medical University of Lviv, Kyiv, Ukraine
  • V.V. MAKSYMYUK Bukovinian State Medical University, Chernivtsy, Ukraine
  • R.A. CHAJKIVSKYJ Danylo Halytskyi National Medical University of Lviv, Kyiv, Ukraine
  • O.V. PRYKUPENKO Danylo Halytskyi National Medical University of Lviv, Kyiv, Ukraine
  • O.M. NEPYIVODA Danylo Halytskyi National Medical University of Lviv, Kyiv, Ukraine
  • T.YU. ROZHANSKYI Volyn Regional Oncology Centre, Lutsk, Ukraine
  • YU.T. MARTYN Second Lviv Territorial Medical Association “Clinical Hospital of Planned Treatment, Rehabilitation and Palliative Care”, Lviv, Ukraine
  • V.R. CHAJKIVSKA Danylo Halytskyi National Medical University of Lviv, Kyiv, Ukraine

DOI:

https://doi.org/10.15407/exp-oncology.2025.01.108

Keywords:

right uterine appendage, mucocele, appendix, appendicular mucinous cystadenoma, cystadenocarcinoma

Abstract

Tumors of the right uterine appendages cannot always be distinguished from mucous neoplasms of the appendix (MA) at the preoperative stage. According to the literature, MA is traditionally considered more common in women than in men at the age of 50 years, with a ratio of 4:1. We have identified 2 cases of surgical treatment of MA in gynecological practice, one of mucinous cystadenoma and the other of mucinous cystadenocarcinoma. We present the visual intraoperative assessment of the appendix condition in cystadenoma and cystadenocarcinoma, clinical manifestations, diagnostic discrepancies, and operative tactics. The literature on the detection of appendicular mucocele that mimics ovarian tumor formations in women has been reviewed. The features of diagnostics and possible diagnostic errors were summarized. Diagnostic laparoscopy, visual and operative clinical experience of the surgeon, and cytological and histological examinations of intra- and postoperative results allow for an adequate treatment. It is advisable that the stages and course of appendectomy be reviewed by operating gynecologists and, if necessary, general surgeons.

References

Givens V, Mitchell GE, Harraway-Smith C, et al. Diagnosis and management of adnexal masses. Am Fam Physician. 2009;80(8):815-820.

American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Gynecology. Practice Bulletin No. 174: Evaluation and Management of Adnexal Masses. Obstet Gynecol. 2016;128(5):e210-e226. https:// doi.org/10.1097/AOG.0000000000001768

Cristian DA, Grama FA, Becheanu G, et al. Low-grade appendiceal mucinous neoplasm mimicking an adnexal mass. Rom J Morphol Embryol. 2015;56(2 Suppl):837-842.

Papoutsis D, Protopappas A, Belitsos P, et al. Mucocele of the vermiform appendix misdiagnosed as an adnexal mass on transvaginal sonography. J Clin Ultrasound. 2012;40(8):522-525. https://doi.org/10.1002/jcu.20858

Sekkat H, El Hamzaoui J, Armel KSK, et al. A colic mesothelial cyst, mimicking an appendicular mucocoele in an elderly patient: a case report and a literature review. J Minim Access Surg. 2024;20(2):229-232. https://doi. org/10.4103/jmas.jmas_199_22

Dhage-Ivatury S, Sugarbaker PH. Update on the surgical approach to mucocele of the appendix. J Am Coll Surg. 2006;202(4):680-684. https://doi.org/10.1016/j.jamcollsurg.2005.12.003

Aho AJ, Heinonen R, Laurén P. Benign and malignant mucocele of the appendix. Histological types and progno- sis. Acta Chir Scand. 1973;139(4):392-400.

Yarema R, Moran B, Cecil T, et al. Peritoneal pseudomyxoma: incurable casuistic pathology or the need for proac- tive combination treatment? Clin Oncol 2017;3:26-31. https://doi.org/10.32471/clinicaloncology.2663-466X

Agrusa A, Romano G, Galia M, et al. Appendiceal mucinous neoplasms: an uncertain nosological entity. Report of a case. G Chir. 2016;37(2):86-89. https://doi.org/10.11138/gchir/2016.37.2.086

Jelev G, Vassilev I, Usheva S, et al. А case of a mucocele of the appendix - a diagnostic and therapeutic dilemma. Int J Surg Case Rep. 2023;105:108082. https://doi.org/10.1016/j.ijscr.2023.108082

Aleter A, El Ansari W, Toffaha A, et al. Epidemiology, histopathology, clinical outcomes and survival of 50 cases of appendiceal mucinous neoplasms: Retrospective cross-sectional single academic tertiary care hospital experience. Ann Med Surg (Lond). 2021;64:102199. https://doi.org/10.1016/j.amsu.2021.102199

Paladino E, Bellantone M, Conway F, et al. Large mucocele of the appendix at laparoscopy presenting as an ad- nexal mass in a postmenopausal woman: a case report. Case Rep Obstet Gynecol. 2014;2014:486078. https://doi. org/10.1155/2014/486078

Ruiz-Tovar J, Teruel DG, Castiñeiras VM, et al. Mucocele of the appendix. World J Surg. 2007;31(3):542-548. https:// doi.org/10.1007/s00268-006-0454-1

Sklyarovа V, Chajkivskyj R, Prykupenko O, et al. Discrepancies between preoperative diagnosis of tumors and the right uterine appendage and intraoperative data. Appendiculare mucocele, which manifests itself in the form of an appendage formation. Clinical case. Ukr J Health Woman. 2023;6(169):65-69; https://doi.org/10.15574/ HW.2023.169.65 (in Ukrainian).

Agha RA, Borrelli MR, Farwana R, et al. The SCARE 2018 statement: Updating consensus Surgical CAse REport (SCARE) guidelines. Int J Surg. 2018;60:132-136. https://doi.org/10.1016/j.ijsu.2018.10.028

Akman L, Hursitoglu BS, Hortu İ, et al. Large mucinous neoplasm of the appendix mimicking adnexal mass in a postmenopausal woman. Int J Surg Case Rep. 2014;5(12):1265-1267. https://doi.org/10.1016/j.ijscr.2014.11.050

Kalogiannidis I, Mavrona A, Grammenou S, et al. Endometrial adenocarcinoma and mucocele of the appendix: an unusual coexistence. Case Rep Obstet Gynecol. 2013;2013:892378. https://doi.org/10.1155/2013/892378

Ayadi C, Naggar A, Andour H, et al. Appendiceal mucocele with pseudomyxoma peritonei mimicking ovarian tumor with peritoneal carcinomatosis. Radiol Case Rep. 2022;17(9):3000-3004. https://doi.org/10.1016/j.radcr.2022.05.028

Derbal S, Klapczynski C, Charissoux A, et al. Management of mucocele of the appendix with peritoneal dissemina- tion in pregnant women: a case report and literature review. Acta Chir Belg. 2023;123(2):185-191. https://doi.org/ 10.1080/00015458.2021.1956800

Noghabaei G, Arab M, Fazli G, et al. A case of appendiceal mucocele mimicking adnexal mass in a young woman with chronic abdominal pain. J Obst Gynecol Cancer Res. 2023;8(3):301-305. https://doi.org/10.30699/jogcr.8.3.301

Hassan Y, Anees A, Peer JA, Yadav M. Three cases of appendiceal mucocele: from diagnosis to management. Saudi J Med Med Sci. 2022;10(3):276-280. https://doi.org/10.4103/sjmms.sjmms_646_21

Alsubaie NR, Ibrahim MA, Nassar MA, Alsalama MI. Appendicular mucinous cystadenoma: a case report. J Surg Case Rep. 2023;10(3):rjad097. https://doi.org/10.1093/jscr/rjad097

Toffaha A, El Ansari W, Aleter A. What you see might not be what you get: Discrepancies between intraoperative findings and preoperative diagnosis of ovarian tumors. Appendicular mucocele presenting as an adnexal mass - Case report and review of literature. Int J Surg Case Rep. 2020;75:543-549. https://doi.org/10.1016/j.ijscr.2020.09.112

Aleter A, El Ansari W. Incidental appendiceal mucinous neoplasm mimicking a left adnexal mass: a case report. Int J Surg Case Rep. 2020;74:132-135. https://doi.org/10.1016/j.ijscr.2020.07.081

Alghamdi AO, Aldossary MY, Alsawidan M, AlBahar S. Low grade appendiceal mucinous neoplasm mimicking an ovarian cyst: a case report. Int J Surg Case Rep. 2020;70:145-148. https://doi.org/10.1016/j.ijscr.2020.04.074

Lomei Y, Demkovich T, Lomei Y. Mucocele/mucinous cystadenocarcinoma of the appendix. Emerg Med. 2021;17(1):67-71. https://doi.org/10.22141/2224-0586.17.1.2021.225724

Gortchev G, Tomov S, Dimitrov D, et al. Appendiceal mucocele presenting as a right adnexal mass: a case report.

Obstet Gynecol Int. 2010;2010:281053. https://doi.org/10.1155/2010/281053

Guio Y, Borraez M, González M, et al. Diagnóstico fortuito de neoplasia mucinosa de apéndice establecido durante la cesárea. Ginecol Obstet Mex. 2023;91(8):600-605. https://doi.org/10.24245/gom.v91i8.8497 (in Spanish).

Khan A, AlSubaie RS, Almohammed Saleh AA. Mucocele of the appendix: a case report and review of literature. Cureus. 2023;15(6):e40168. https://doi.org/10.7759/cureus.40168

Downloads

Published

11.07.2025

How to Cite

SKLYAROVА V., MAKSYMYUK, V., CHAJKIVSKYJ, R., PRYKUPENKO, O., NEPYIVODA, O., ROZHANSKYI, T., … CHAJKIVSKA, V. (2025). APPENDICULAR MUCINOUS CYSTADENOMA AND CYSTOADENOSARCOMA IN GYNECOLOGICAL PRACTICE. CLINICAL CASES AND LITERATURE REVIEW. Experimental Oncology, 47(1), 108–114. https://doi.org/10.15407/exp-oncology.2025.01.108