CHOLANGIOCARCINOMA IN TWIN PREGNANCY: A CASE REPORT

Authors

  • V.L. DRONOVA SI “All-Ukrainian Center for Motherhood and Childhood” of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
  • O.I. DRONOV SI “All-Ukrainian Center for Motherhood and Childhood” of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
  • S.A. LYALKIN SNE “National Cancer Institute” of Ministry of Health of Ukraine, Kyiv, Ukraine
  • O.M. MOKRYK SI “All-Ukrainian Center for Motherhood and Childhood” of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
  • R.S. TESLYUK SI “All-Ukrainian Center for Motherhood and Childhood” of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine

DOI:

https://doi.org/10.15407/exp-oncology.2025.01.096

Keywords:

cholangiocarcinoma, pregnancy, case report

Abstract

Cholangiocarcinoma during pregnancy is a very rare condition. We present the case of a 35-year-old pregnant woman with intrahepatic cholangiocarcinoma. To our knowledge, this is the first case of cholangiocarcinoma in a patient with twin pregnancy. At 25 weeks of gestation, surgical intervention was performed: right-sided hemihepatectomy, lymphadenectomy D3, and diaphragmatic peritoneumectomy on the right side. At 33 weeks of pregnancy, a cesarean section was performed. Currently, the patient is receiving chemotherapy. A multidisciplinary approach should be a standard workup in making decisions regarding the treatment strategy for a pregnant patient with a cancer diagnosis

References

Silverstein J, Annalisa L, Chien A, et al. Multidisciplinary management of cancer during pregnanacy. JCO Oncol Pract. 2020;16(9):545-557. https://doi.org/10.1200/OP.20.00077

Wolters V, Heimovaara J, Maggen C, et al. Management of pregnancy in women with cancer. Int J Gynecol Cancer. 2021;31(3):314-322. https://doi.org/10.1136/ijgc-2020-001776

de Haan J, Verheecke M, Van Calsteren K, et al.Oncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20-year international cohort study of 1170 patients. Lancet On- col. 2018;19:337-346. https://doi.org/10.1016/S1470-2045(18)30059-7

Masturzo B, Parpinel G, Macchi C, et al. Impact of cancer in the management of delivery: 10 years of variations.

J Matern Fetal Neonatal Med. 2020;33:2006-2011. https://doi.org/10.1080/14767058.2018.1536117

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin 2019;69:7-34. https://doi.org/10.3322/ caac.21551

Doherty B, Nambudiri VE, Palmer WC. Update on the diagnosis and treatment of cholangiocarcinoma. Curr Gas- troenterol Rep. 2017;19(01):2. https://doi.org/10.1007/s11894-017-0542-4

Francis AP, Chang M, Dolin CD, et al. Recurrent cholangiocarcinoma in pregnancy: a case report. AJP Rep. 2018;8(4):e261-e263. https://doi.org/10.1055/s-0038-1675376

Washburn L, Mahipal A, Jatoi A, et al. Postpartum related intrahepatic cholangiocarcinoma with FGFR2 fusion and severe hyperbilirubinemia with response to FGFR inhibitor pemigatinib: case report and review. J Gastrointest Oncol. 2023;14(6):2627-2636. https://doi.org/10.21037/jgo-23-693

Oh DY, Ruth He A, Qin S, et al. Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer. NEJM Evidence 2022;1:EVIDoa2200015 https://doi.org/10.1056/EVIDoa2200015

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Published

11.07.2025

How to Cite

DRONOVA, V., DRONOV, O., LYALKIN, S., MOKRYK, O., & TESLYUK, R. (2025). CHOLANGIOCARCINOMA IN TWIN PREGNANCY: A CASE REPORT. Experimental Oncology, 47(1), 96–101. https://doi.org/10.15407/exp-oncology.2025.01.096

Issue

Vol. 47 No. 1 (2025): Experimental Oncology

Section

Case report

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