Assessment of trace elements in serum of acute lymphoblastic and myeloid leukemia patients
DOI:
https://doi.org/10.32471/exp-oncology.2312-8852.vol-41-no-1.12730Keywords:
acute lymphoblastic leukemia, acute myeloid leukemia., copper, selenium, spectrophotometry, zinc.Abstract
Summary. Aim: Trace elements play a key role in human metabolism. The aim of the present study was to measure essential trace elements in the serum of patients with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Materials and Methods: 32 patients with ALL and 16 patients with AML were studied. The control group consisted of 36 subjects. Serum levels of the trace elements selenium, copper and zinc were measured by spectrophotometry. Results: The mean of copper concentrations in the groups of patients with AML and ALL was significantly higher than in the control group (p < 0.0001), whereas serum levels of selenium and zinc were significantly lower in AML patients (p < 0.0001). Also in ALL patients the levels of selenium and zinc were significantly decreased compared with the control group (p < 0.0001; p = 0.0003). Conclusion: Our results indicate that the levels of zinc and selenium are significantly decreased and copper levels are significantly increased in the serum of patients with acute leukemia (AML, ALL).
References
Chan K. Acute lymphoblastic leukemia. Curr Probl Pediatr Adolesc Health Care 2002; 32: 40–9.
Döhner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European Leukemia Net. Blood 2010; 115: 453–74.
Gul-Uludağ H, Valencia-Serna J, Kucharski C, et al. Polymeric nanoparticle-mediated silencing of CD44 receptor in CD34+ acute myeloid leukemia cells. Leuk Res 2014; 38: 1299–308.
Lowenberg BR, Downing J, Burnett A. Acute myeloid leukemia. N Engl J Med 1999; 341: 1051–62.
Schwartz MK. Role of trace elements in cancer. Cancer Res 1975; 35: 3481–7.
Gundogdu M, Kaya H, Gulcin I, et al. Oxidase activity of ceruloplasmin and some acute phase reactant and trace element concentrations in serum of patients with chronic lymphocytic leukemia. Med J 2007; 52: 24-7.
Wiernsperger N, Rapin J. Trace elements in glucometabolic disorders: an update. Diabetol Metab Syndr 2010; 2: 70.
Azin F, Raie RM, Mahmoudi MM. Correlation between the levels of certain carcinogenic and anticarcinogenic trace elements and esophageal cancer in northern Iran. Ecotoxicol Environ Saf 1998; 39: 179–84.
Guidotti TL, McNamara J, Moses MS. The interpretation of trace element analysis in body fluids. Indian J Med Res 2008; 128: 524–32.
Cui Y, Vogt S, Olson N, et al. Levels of zinc, selenium, calcium, and iron in benign breast tissue and risk of subsequent breast cancer. Cancer Epidemiol Biomarkers Prev 2007; 16: 1682–5.
Yelinova V, Glazachev Y, Khramtsov V, et al. Studies of human and rat blood under oxidative stress: changes in plasma thiol level, antioxidant enzyme activity, protein carbonyl content, and fluidity of erythrocyte membrane. Biochem Biophys Res Commun 1996; 221: 300–3.
Levy MA, Tsai YH, Reaume A, Bray TM. Cellular response of antioxidant metalloproteins in Cu/Zn SOD transgenic mice exposed to hyperoxia. Am J Physiol Lung Cell Mol Physiol 2001; 281: 172–82.
Nemoto K, Kondo Y, Himeno S, et al. Modulation of telomerase activity by zinc in human prostatic and renal cancer cells. Biochem Pharmacol 2000; 59: 401–5.
Antoniades V, Sioga A, Dietrich EM, et al. Is copper chelation an effective anti-angiogenic strategy for cancer treatment? Med Hypotheses 2013; 81: 1159–63.
Yoshizawa K, Willett WC, Morris SJ, et al. Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer. J Natl Cancer Inst 1998; 90: 1219–24.
Subramanyam D, Subbaiah KV, Rajendra W, Lokanatha V. Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment. Exp Oncol 2013; 35: 97–100.
de Rosa V, Erkekoğlu P, Forestier A, et al. Low doses of selenium specifically stimulate the repair of Oxidative DNA damage in LNCaP prostate cancer cells. Free Radic Res 2012; 46: 105–16.
Mark SD, Qiao YL, Dawsey SM, et al. Prospective study of serum selenium levels and incident esophageal and gastric cancers. J Natl Cancer Inst 2000; 92: 1753–63.
Hrgovic M, Tessmer CF, Thomase FB, et al. Significance of serum copper levels in adult patients with Hodgkin’s disease. Cancer 1973; 31: 1337–45.
Westman NG, Marklund SL. Copper and Zinc-containing superoxide dismutase and manganese-containing superoxide dismutase in human tissues and human malignant tumors. Cancer Res 1981; 41: 2962–6.
Mulware SJ. Comparative trace elemental analysis in cancerous and noncancerous human tissues using PIXE. J Biophys 2013; 2013: 192026.
Li Y, Xue Q, Chen L, et al. Research on relationships of gastric cancer with serum trace elements, Helicobacter pylori and COX-2 in gastric tissue. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2004; 21: 107–10.
Santoliquido PM, Southwick HW, Olwin JH. Trace metal levels in cancer of the breast. Surg Gynecol Obstet 1976; 142: 65–70.
Cobanoglu U, Demir H, Sayir F, et al. Some mineral, trace element and heavy metal concentrations in lung cancer. Asian Pac J Cancer Prev 2010; 11: 1383–8.
Zuo XL, Chen JM, Zhou X, et al. Levels of selenium, zinc, copper, and antioxidant enzyme activity in patients with leukemia. Biol Trace Elem Res 2006; 114: 41–53.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Experimental Oncology
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
