THE EFFECT OF “LOSHTAK” PREPARATION ON EXOGENOUS AND ENDOGENOUS OXIDATIVE DNA DAMAGE IN TRANSFORMED HUMAN CELLS
“Loshtak” preparation (LP) (standardized Bryonia alba roots) is used in Armenia as an adaptogenic drug with stress-protective and tonic properties to increase the non-specific resistance of an organism toward harmful stimuli. The effect of aqueous and methanol extracts of LP on exogenous and endogenous oxidative DNA damage was studied on transformed human cells (HeLa and Caco-2) using single cell gel electrophoresis (the comet assay). Extracts of LP lack ability to protect human transformed cells against exogenous DNA oxidative damage induced by H2O2. The ability of LP to protect human cells against endogenous oxidative DNA damage adds a new beneficial property to other effects of it.
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