THE MODIFICATION OF CANCER VACCINE PREPARED ON THE BASE OF METABOLIC PRODUCTS OF B.SUBTILIS 7025 WITH THE USE OF SORBENTS AND AUTOMACROPHAGES

Dvorschenko O.S., Lisovenko G.S., Kovalenko N.G., Potebnya G.P., Kikot V.V., Pozur V.K., Golub A.A.

Antitumor efficacy of the vaccine prepared on the base of glycoproteid, isolated from broth culture filtrate of B.subtilis 7025 (AVG) modified using sorbents and autologous peritoneal macrophages (APM) was studied in vivo. The treatment of sarcoma 37-bearing mice with vaccine in combination with sorbent and peritoneal cells resulted in inhibition of tumor growth, 1.5–3-fold increase of longevity, and the improvement of indices of humoral and cellular immunity.

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