CYTOGENETICAL INVESTIGATION OF TUMOR CELLS IN PATIENTS WITH OVARIAN AND ENDOMETRIAL CANCER

Polishchuk L.Z.1, Nesina I.P.2, Buchynska L.G.*1, Vorobyova L.I.3, Svintsitsky V.S.3

Summary. In the work, the cytogenetic investigation of tumor cells from 28 patients with II–III stages of ovarian cancer, 44 patients with I–II stages of endometrial cancer and 7 patients with endometrial hyperplasia was carried out. The quantitative and structural changes of chromosomes, the nucleolar organizer regions (AgNORs) in tumor cells isolated from ascite fluid of patients with ovarian cancer, and from surgically resected tumors of patients with endometrial cancer were analyzed. It has been shown that AgNOR’s content in tumor cells depends from the level of differentiation of endometrial tumors. The variations of cytogenetic characteristics reflect the genetic heterogeneity of ovarian and endometrial cancer and possess the individual index of malignant degree of these tumors.

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