ANTIMETASTATIC EFFECT OF THE PREPARATION OF THIOPHOSPHOROUS ACID AND CELANDINE ALCALOIDS IN VIVO AFTER REMOVAL OF PRIMARY TUMORS

Khranovskaya N.N.1, Shalimov S.A.2, Grinevich Yu.A.1, Kad’kalenko A.G.3

Summary. On the model of Lewis lung carcinoma after surgical removal of primary tumor, a significant antimetastatic effect of preparation on the basis of Chelidonium majus L. components (thiophosphorous acid and celandine alkaloids — TPACA) was recorded. Antimetastatic effect of TPACA has prolonged character and is maximal at the remote terms after the course of TPACA therapy. The preparation also rendered significant positive effect on some indices of the immune system, in particular, on the level of serum interferon and cytotoxic activity of splenocytes. Besides, the preparation promoted the increase of BGL content and stabilized the number of neutrophiles and monocytes in peripheral blood of tumor-bearing animals.

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