STAGE OF DIFFERENTIATION, PROLIFERATIVE INDEX OF TUMOR CELLS AND CYTOTOXIC ACTIVITY OF PERIPHERAL BLOOD LYMPHOCYTES IN COLORECTAL CANCER PATIENTS

Paholyuk Tatyana D., Zacharzeva Lubov M., Koshel' Konstantin V., Oliynichenko Gennadiy P., Berezhnaya Ninel M.

Aim: To evaluate prognostic value of activity of cytotoxic lymphocytes of peripheral blood (CTL) of patients with colorectal cancer (CRC). Methods: 2-year survival of 30 patients with colorectal cancer stage II (T2–3N0–1M0G1–3) was investigated in relation with clinical data, cytotoxic activity of peripheral blood lymphoсytes (by МТТ-test) and immunohistochemical peculiarities of tumor cells using anti-Ki-67-MABs. Results: It was revealed that some factors had prognostic significance, namely regional lymph nodes involvement (r = –0.69), proliferative activity of tumor cells (Ki-67-positivity) (r = –0.67), restoration of CTL function after operation (r = 0.46), adjuvant chemotherapy (r = 0.41) and differentiation stage of tumor (r = 0.40). Negative correlation between CTL activity before operation and tumor proliferative activity also exists (r = –0.35). Conclusion: the data point to the involvement of natural killer cells in the control of tumor growth.

No Comments » Add comments
Leave a comment

ERROR: si-captcha.php plugin says GD image support not detected in PHP!

Contact your web host and ask them why GD image support is not enabled for PHP.

ERROR: si-captcha.php plugin says imagepng function not detected in PHP!

Contact your web host and ask them why imagepng function is not enabled for PHP.