RETROTRANSPOSABLE ACTIVATION OF ALU ELEMENTS, GENOMIC INSTABILITY AND CARCINOGENESIS

Rui-BaoTang, YangYuan, KangYing, Hou-QiLiu, Kai-MengHu

Alu elements are the most abundant short interspersed repetitive elements (SINEs). Providing insertion mutations or hot spots for unequal homologous recombination (HR), Alus contribute to varieties of genomic diseases. With probes sharing significant similarity with Alus, we performed in situ hybridization to analyze paraffin sections of hepatoma and found that abundance of Alu RNA was notably higher in hepatoma than in adjacent tissues. Based on observations of others laboratories, we speculate that retrotransposable activation of Alu elements might cause genomic instability during carcinogenesis.

No Comments » Add comments
Leave a comment

ERROR: si-captcha.php plugin says GD image support not detected in PHP!

Contact your web host and ask them why GD image support is not enabled for PHP.

ERROR: si-captcha.php plugin says imagepng function not detected in PHP!

Contact your web host and ask them why imagepng function is not enabled for PHP.