PHOTODYNAMIC EFFICACY OF TOPICAL APPLICATION OF CHLORIN E6 — POLYVINYL PYRROLIDONE COMPLEX IN TUMOR-BEARING RATS

Istoтin Y.Р., Laptsevich T.P., Bizyuk S.A., Alexandrova E.N.

Aim: To evaluate the antitumor efficacy of photodynamic therapy with ointment form of chlorin e6 — polyvinyl pyrrolidone complex. Methods: 2 or 5% chlorin e6 ointment was applied on the surface of rat SM-1 tumor for 15 min — 5 h, and then tumors were scored for photosensitizer accumulation and tissue damage induced by laser irradiation. Results: Selectivity of chlorin e6 accumulation in tumor tissues considerably increases when photosensitizer was applied topically compared with intravenous administration. Antitumor efficacy of photodynamic therapy using topical application of chlorin e6 — polyvinyl pyrrolidone complex is just as high as upon intravenous administration of the preparation. Conclusion: The level of tissue accumulation of chlorin e6 — polyvinyl pyrrolidone complex administered in ointment form allows to carry out fluorescence diagnosis and PDT of superficially localized malignant tumors.

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