EFFECT OF PHOTODYNAMIC THERAPY ON TUMOR ANGIOGENESIS AND METASTASIS IN MICE BEARING LEWIS LUNG CARCINOMA

Lisnjak I.O., Kutsenok V.V., Polyschuk L.Z., Gorobets O.B., Gamaleia N.F.

Aim: To investigate the influence of photodynamic therapy (PDT) on the tumor angiogenesis and metastasis. Methods: The effect of PDT with a photosensitizer 5-aminolaevulinic acid (ALA) on tumor metastasis and angiogenesis was studied on the model of subcutaneously implanted Lewis lung carcinoma (3LL) in C57Вl/6 mice. VEGF level in blood serum of animals was evaluated by ELISA. Results: It has been shown that application of ALA-PDT resulted in the lowered rate of metastatic spreading and decreased VEGF level in blood serum of 3LL-bearing mice, and morphologic alterations of vascular system in tumor tissue. Conclusion: The antitumor action of PDT using ALA as a photosensitizer is caused partly by antimetastatic and photodamaging effect mediated by vascularization disturbances in tumor tissue.

No Comments » Add comments
Leave a comment

ERROR: si-captcha.php plugin says GD image support not detected in PHP!

Contact your web host and ask them why GD image support is not enabled for PHP.

ERROR: si-captcha.php plugin says imagepng function not detected in PHP!

Contact your web host and ask them why imagepng function is not enabled for PHP.