Prognostic value of SCCA tumor marker in patients with cervical cancer
L. Vorobijva, I. Goncharuk, S. Nespryadko
National Cancer Institute, Kyiv, Ukraine
Squamous cell carcinoma antigen (SCCA) level in blood serum is proven to be valuable for diagnosis and monitoring of patients with cervical carcinoma. Since cervical carcinoma as a rule originates from squamous epithelium, SCCA estimation in blood serum is significant for the study of the disease development. The aim of the study was to monitor SCCA level in patients with cervical carcinoma with primary and metastatic disease for determination of recurrence probability value. Patients and Methods: Changes in SCCA level in blood serum and clinical data were analyzed in 224 patients with cervical carcinoma of I-IV stage. Primary cancer was diagnosed in 171 patients; recurrence was confirmed in 53 patients. SCCA concentration in blood serum was determined by chemiluminescent immunoassay at micro particles (HIAM). Statistical analysis was performed with the use of Statistica 6.0 software. The study protocol was approved by Ethical Committee permission of National Cancer Institute (Kyiv, Ukraine). Results: It was shown that SCCA values different reliably in groups of patients with different development of the disease (p<0.05). SCCA level in patients with Ca in situ and IA stage was equal to 0.6 ± 0.1 and 0.9 ± 0.1 ng/mL, respectively. At the higher stage of the disease, the higher SCCA level in blood serum was detected (l 5.9 ± 1.4 ng/mL in IIIB stage). It was confirmed that SCCA level in patients with primary cervical cancer with metastases in regional lymph nodes was higher compared to SCCA level in patients without metastases (5.6 ±1.4 ng/mL vs 2.3 ± 0.1 ng/mL, p < 0.05). SCCA level in blood serum increased up to 86.4% of patients with the recurrence and equaled 19.4 ± 3.7 ng/mL (from 0.5 to 70.0 ng/mL). SCCA value in blood serum increased up to 60.4% of patients with cervical carcinoma of IB-III stage. Test-sensitivity increased from 7.8% (I stage) to 77.8% (III stage). Conclusion: SCCA level in blood serum can be considered as a sensitive method in prognostic study and determination of disease stage in patients with cervical carcinoma.
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