The second Ukrainian-Swedish workshop “Translational Oncology: Old and New Paradigms”

The second Ukrainian-Swedish workshop “Translational Oncology: Old and New Paradigms” took place at the R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine (IEPOR NASU) on May 20–21, 2013. Karolinska Institutet (Stockholm, Sweden) was co-organizer of the event.

Academician Vasyl F. Chekhun, the director of R.E. Kavetsky IEPOR NASU, opened the conference with a welcoming speech. He greeted participants and stressed the importance of knowledge integration in field of cancer research. He also pointed out the necessity of experience exchange and collaboration between different institutes worldwide.

The goal of the Workshop was to discuss current views and newly emerging conceptual frameworks concerning mechanisms of cancer development. Considering the fact that cancer is major healthcare problem today, the pursuit of deep understanding how cancer actually works will lead to new effective approaches to treatment of proliferative disorders. Accordingly, all lectures and reports, presented by participants, included up-to-date issues and experimental data dealing with clinical and biological aspects of cancer research. The Workshop featured excellent lectures, delivered by invited speakers from Karolinska Institutet (Sweden) and speakers from IEPOR NASU, as well as informative reports on proceeding research.

The number of scientists, who took part in the event, reached more than hundred people this year. Apart of organizing institutes representatives of other institutions also attended the Workshop. Among them there were Institute of Cell Therapy, City Clinical Oncological Center, National Cancer Institute of the Ministry of Public Health of Ukraine, National University of Kyiv-Mohyla Academy, Center of Molecular and Cell Research, Taras Shevchenko National University of Kyiv, Educational and Scientific Center “Institute of Biology”, State Institution “Institute of Pharmaco­logy and Toxicology, National Research Center for Radiation Medicine, Shupik National Medical Academy of Post-Graduate Education, Reference-Centre for Molecular Diagnostic, Ovcharenko Institute of Biocolloidal Chemistry, Bogomolets National Medical University, Institute of Molecular Biology and Genetics (Kyiv, Ukraine), Danylo Galytskyj Lviv National Medical University, Ivano-Frankivsk National Medical University, Rivne Region Oncology Hospital, Bila Tserkva National Agrarian University; Bila Tserkva Regional Oncology Center; Belarusian Research Сenter for Pediatric Oncology, Hematology and Immunology (Minsk, Belarus), Cancer Research Institute of SB of the RAMS (Tomsk, Russia), Institute of Chemical Biology and Fundamental Medicine of SB of the RAS (Novosibirsk, Russia).

The program of the Workshop spanned plenary lectures and oral or poster reports. All talks evoked vivid interest among listeners and, thus, were thoroughly discussed. Some of these reports were included into current issue of Experimental Oncology journal for your appreciated consideration.

Part I. LECTURES

  1. Tumor progression — time for a new paradigm?
  2. Exploiting the p53 pathway to achieve cure in chronic myelogenous leukemia
  3. Individualization of cancer treatment: successes and challenges
  4. High-risk HPV L1 capsid protein as a marker of cervical intraepithelial neoplasia in high-risk HPV-positive women with minor cytological abnormalities
  5. Carcinoma of the endometrium: prediction markers of tumour progression, aggressiveness and potential targets for therapy in a mitochondrial perspective
  6. EBV-encoded EBNA-5 binds to p18ARF and prevents p53-induced growth arrest and apoptosis
  7. Transcriptional network in B cells: IRFS in the development of B cells and lymphomagenesis
  8. Immunogenic cancer cell death: how it can be exploited
  9. Human beta-defensins in regulation of biologic patterns of cancer cells

Part II. ORAL and Poster presentations

  1. New mechanisms of clinical efficacy of low-dose metronomic chemotherapy treatment of patients with metastatic colorectal cancer
  2. The comet assay: applications to study cancer risk influenced by external exposure
  3. Antitumor effect of OXY correlates with its ability to decrease the level of nitrosyl-hem complexes in lewis lung carcinoma cells
  4. Combined application of autologous and xenogeneic heat shock proteins in vaccinotherapy of malignant tumors
  5. Mismatch repair proteins MSH2, MLH1 expression and DNA damage in tumor cells of endometrial cancer patients with family history of cancer
  6. The influence of the pelvic plexus preservation under radical hysterectomy in patients with infiltrative cervical cancer on the contractile function of the urinary bladder
  7. Alterations in functional properties of bone marrow stem cells in chronic myeloid leukemia patients with different response to tyrosine kinase inhibitors treatment
  8. The frequency of hormone-related tumors in breast cancer patients after surgical treatment
  9. Evaluation of intraperitoneal hyperthermic chemoperfusion efficiency for chemoresistant ovarian cancer
  10. Prognostic value of SCCA tumor marker in patients with cervical cancer
  11. Ovarian tissue cryoconservation in patients with gynecological cancer
  12. Modern chemoimmunotherapy approach based on dendritic cells and low-dose cisplatin in experiment
  13. The role of CD150 surface receptor in regulation of topology and expression of p50 and p65 NF-kB in normal B cells
  14. Molecular-genetic markers for diagnosis and prognosis in pediatric solid malignancies
  15. Nucleic acid markers in blood plasma of patients with colorectal cancer
  16. Complex Information System with Web-interface Concerning Breast Cancer
  17. Significance of COX-2 and VEGF expression in tumor for estimation of treatment results IN cervical cancer stage IIB
  18. A comparison of multiplex short tandem repeat PCR and real-time PCR insertion/deletion polymorphisms methods for quantification of chimerism after hematopoietic stem cell transplantation
  19. Matrix metalloproteinases 2 and 9 activity and tumor-associated macrophages in human gastric cancer: correlation with metastasis
  20. Gene expression of activating transcription factor 5 as a predictor of survival in germinal cell diffuse large B-cell lymphoma
  21. Aberrant expression of IKZF1 gene in blast cells of childhood acute lymphoblastic leukemia
  22. Creation of new combinations of antitumor remedies (experimental study)
  23. The role of pro- and antioxidant processes in DNA damage originating from combined effects of environmental factors and tumor growth
  24. The clinical efficacy of drugs of “Erbisol” class in the treatment of colorectal cancer patients with liver metastases
  25. Molecular genetic studies in patients with cancer and benign tumor of the female reproductive system from the families with history of cancer
  26. Aberrantly methylated circulating DNA as a tool for diagnostics and evaluation of therapeutic effect in lung cancer
  27. Peculiarities of modifying effects of chemical agents on the formation of radiation-induced damage IN genetic apparatus of human cells
  28. Comparative analysis of polymerase chain reaction and conventional cytological examination for peritoneal recurrence risk assessment in patients undergoing surgery for colorectal cancer
  29. The predictive model of chemotherapy response in multiple myeloma patients
  30. Expression of CD44 and Е-cadherin in the serous ovarian cancer and its clinical significance
  31. The role of some cytokines as a local microenvironment in breast cancer progression
  32. Connections of serum and tumor ferritin levels with sensitivity to neoadjuvant chemotherapy in breast cancer patients
  33. Gold nanoprisms as potential delivery agents for photodynamic therapy photosensitizers
  34. Characteristic of HLA-genotype in children with all and AML
  35. Photodynamic therapy of tumors with controlled delivery of photosensitizer hematoporphyrin
  36. The prognostic value of leukemic stem cells percentage in B-lineage childhood acute lymphoblastic leukemia
  37. Role of endometrial hyperplasia in prognosis of survival of patients with ovarian cancer
  38. The phospho-c-Jun content in gastric mucosa cells under experimental gastric carcinogenesis
  39. Epidemiological and experimental approaches for risk assessment of low intensity radiofrequency radiation on the public health effects
  40. Decrease of postneurolytic pain in patients with advanced pancreatic cancer after paravertebral neurolytic block
  41. Features of treatment of the breast cancer patients with disseminated tumor cells and overproduction of tumor necrosis factor in bone marrow
  42. Effect of a fenugreek on lifetime of experimental rodentS with transplanted tumors
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