Effect of a fenugreek on lifetime of experimental rodentS with transplanted tumors

Zhylenko V.

V. Zhylenko

R.E. Kavetsky Institute of Experimental Pathology, Oncology and RadiobiologyNAS of Ukraine, Kyiv, Ukraine

gilenkovv@yandex.ru

Introduction: Recent studies show that Trigonella foenum graecum (Leguminosae family), commonly known as fenugreek, has growth-inhibiting activity against some kinds of experimental tumors. Aim: To study the effect of fenugreek on lifespan of tumor bearing animals. Materials and Methods: Experiments were carried out on the adult C57Bl/6 female mice with subcutaneously grafted Ca755 mammary carcinoma, and adult C57Bl/6 male and female mice transplanted with Lewis lung carcinoma (3LL). The animals in the experimental group were administered with the mix of fenugreek powder (250 mg/kg of body weight) canadian pharmacy vicodin and standard mash from the day of tumor grafting up to the end of experiments. All experiments were carried out according to the rules of local Ethic Committee and were approved by the Ethic Board of IEPOR NASU. Results: The fenugreek consumption increased the lifetime of Ca755 carcinoma mice by 19%, and 3LL-bearing male and female mice by 9% and 26%, respectively. Moreover, it was shown that fenugreek consumption has resulted in the inhibition of Ca755 adenocarcinoma growth by 48%. Anti-metastatic effect of mentioned agent was also observed: an average volume of the metastases per animal was decreased by 86% and 18% in the female and male mice, respectively. Conclusions: The results have shown that fenugreek can be considered a potential anticancer agent with more significant effect in the female animals.

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