HEMATOLOGICAL  DISORDERS INDUCED BY IRRADIATION  IN HIROSHIMA AND  CHERNOBYL:  ANALYSIS  OF MYELOPEROXIDASE-NEGATIVE  ACUTE LEUKEMIAS BY FLOW CYTOMETRY AND POINT MUTATIONS OF p53 SUPPRESSOR  ONCOGENE  IN MYELODYSPLASTIC SYNDROME

Imamura N.

Summary. The use of monoclonal antibodies for identification or characterization of heterogeneous acute unclassifiable leukemias (AULs) enables us not only to define these tumors of lymphoid, myeloid, and megakaryocytic cell origin but also to identify accurately the state of differentiation and their relationship to their normal counterparts, the lymphoid, myeloid, and megakaryocytic cells. In addition, accurate diagnosis should facilitate provision of effective therapies for AULs by means of various clinical applications.

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