THE INFLUENCE OF PSYCHOEMOTIONAL STATUS ON METASTASIS OF LEWIS LUNG CARCINOMA AND HEPATOCARCINOMA-29 IN MICE OF C57BL/6J AND CBA/LAC STRAINS

Kudryavtseva N.N., Tenditnik M.V., Nikolin V.P., Popova N.A., Kaledin V.I.

Aim: To study the influence of psychoemotional status on the development of experimental lung metastases of strain-specific murine Lewis lung carcinoma in C57BL/6J mice and hepatocarcinoma-29 in CBA/Lac male mice. Materials and Methods: Sensory contact model was used for generating animals with repeated experience of social victories or defeat in daily agonistic interactions. Tumor cells were injected into the tail vein after 20 days of agressive confrontations and the number of metastases in the lung was calculated 16 days later. Results: The experimental metastasis is shown to develop differently in mice with opposing social experience: the winners of both strains had significantly less metastases in the lung than the losers. Conclusion: The results obtained indicate that psychoemotional status affects Lewis lung carcinoma and hepatocarcinoma-29 metastasis in male mice.

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