ROLE OF THE UBIQUITIN-PROTEASOME PROTEIN DEGRADATION PATHWAY IN CARCINOGENESIS, TUMOR PROGRESSION AND SUSCEPTIBILITY TO TUMOR TREATMENT

Sjakste N., Sjakste T., Vikmanis U.

The review summarizes data on involvement of the proteasomes and other enzymes performing the ubiquitin-mediated proteolysis in carcinogenesis, tumor biology and mechanisms of action of antitumor drugs. Increased or decreased susceptibility of oncoproteins and tumor suppressors can give rise to tumorigenesis. Proteasome composition and proteasome activity is altered in neoplastic cells. Novel antitumor drugs can be developed from the proteasome inhibitors.

No Comments » Add comments
Leave a comment

ERROR: si-captcha.php plugin says GD image support not detected in PHP!

Contact your web host and ask them why GD image support is not enabled for PHP.

ERROR: si-captcha.php plugin says imagepng function not detected in PHP!

Contact your web host and ask them why imagepng function is not enabled for PHP.