INHIBITION AND MODIFICATION OF BENZO(a)PYRENE INDUCED CHEMICAL CARCINOGENESIS BY ASCORBIC ACID ALONE OR IN COMBINATION WITH a-TOCOPHEROL IN WISTAR RATS

Karkabounas S.1, Binolis J.1, Zelovitis J.2, Kotsis N.2, Charalabopoulos A.3, Avdikos A.2, Zuridakis A.2, Liasko R.2, Giannakopoulos X.2, Charalabopoulos K.

Summary. Inhibition/modification of chemical carcinogenesis induced by benzo(a)pyrene in 496 male Wistar rats by treatment with ascorbic acid alone or in combination with a-tocopherol was investigated in this study. The carcinogenic and anticarcinogenic potencies of substances used were calculated by using the animals mean survival time from each studied group. It was proven that ascorbic acid exerts an anticarcinogenic potency of 7.2 units; its combination with a-tocopherol highly enhances the anticarcinogenic potency to 20.1 units. A statistically significant difference was found between the control group and the animal group treated with ascorbic acid as well as between the control group and the group of animals treated with the combination of ascorbic acid/a-tocopherol. Furthermore, a statistically significant difference regarding the mean survival time in days was found between the animal group treated with ascorbic acid alone and the other animal group treated with the ascorbic acid/a-tocopherol combination (p < 0.001). In conclusion, antioxidants like ascorbic acid and a-tocopherol may inhibit or modify chemical carcinogenesis induced by benzo(a)pyrene.

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