STRUCTURAL ALTERATIONS OF PLASMA MEMBRANES OF GUERIN’S CARCINOMA CELLS UPON THE DEVELOPMENT OF RESISTANCE TO DOXORUBICINE

Chekhun V.F., Lebed O.I., Tryndyak V.P., Makovetskiy V.P., Todor I.N., Kulik G.I.

The alteration of structural properties of plasma membranes (PM) of Guerin’s carcinoma cells (GC) upon the development of the resistance to doxorubicine (DOX) was carried out by fluorescent methods. It has been shown that PM of DOX-resistant GC cells are characterized by more weak packing of proteins, lower immersion of proteins in lipid bilayer and higher microviscosity of lipid regions than the ones from DOX-sensitive GC cells.

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