IMMUNOSTIMULATORY CpG DNA IN CANCER VACCINOTHERAPY

Olishevsky S.V., Kozak V.V., Yanish Y.V., Shlyakhovenko V.A.

Summary. In the review, recent data on the application of CpG DNA in immunotherapy and cancer vaccinotherapy are presented. Preliminary studies confirmed that administration of CpG DNA alone or in combination with other agents may be effective in a variety of cases and that CpG DNA may be used as a potent immune adjuvant. Some possible molecular mechanisms responsible for the immunostimulatory effects of CpG DNA are discussed.