PREFERENTIAL COEXPRESSION OF THE FUNCTIONALLY ACTIVE RECEPTORS FOR EGF AND TRANSFERRIN IN SOME HUMAN TUMOR CELL LINES OF THE EPITHELIAL ORIGIN

Phylchenkov A.A., Slukvin I.I., Kudryavets Yu.I.

Expression of epidermal growth factor receptor (EGF-R) and transferrin receptor (Trf-R) have been studied by flow cytometry in 14 human tumor cell lines. A positive and highly significant correlation between the levels of the EGF-R and Trf-R has been observed in tumor cell lines of epithelial origin. No such relationship was found in tumor cells of other histogenesis, except of HT-1080 fibrosarcoma cell line. It was also shown that EGF-R and Trf-R determined by flow cytometry are functionally active because exogenously added EGF and transferrin induced DNA synthesis in cells under study. We conclude that coexpression of EGF-R and Trf-R is specific for tumor epithelial cells and may serve as one of the mechanisms for maintenance of the neoplastic state. In addition, reported findings are extensively discussed as an experimental basis for clinical settings.

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