EFFECT OF TRACE ELEMENT SOLUTION ON RADIOSENSITIVITY OF TRANSPLANTABLE RAT TUMORS

Grinevich Yu.A., Beres Jr.J., Zinchenko V.A., Martynenko S.V.

Undiluted Beres Drops Plus (BDP) preparation administrated intraperitoneally to noninbred rats (wild strain and radioresistant strain) with Guerin carcinoma or Pliss lymphosarcoma increased the mitotic activity of tumor cells. In combination with radiotherapy, BDP administered before the 1st and 3rd fractions of irradiation (at the peak of mitotic activity) enhanced the efficacy of radiotherapy. The beneficial effect manifested itself in the inhibition of tumor growth and increased survival rate. Restoration of the thymic endocrine function contributed to the good therapeutic effect of the combination of radiotherapy with BDP treatment in rats with Guerin carcinoma.

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