CLINICAL VALUE OF CD-ANTIGEN EXPRESSION PATTERNS ON BLAST CELL IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

Lenskaya R.V., Kolenkova G.V., Timakov A.M.

167 children aged under 15 with newly diagnosed ALL have been studied using the comprehensive panel of antibodies against 7 myeloid antigens (AGs), 7 T-linear AGs, 6 B-linear AGs, and 5 AGs associated with proliferation and activation. B-ALL was diagnosed in 146 cases, and T-ALL — in 21 cases. The BFM-90 and MB-91 program treatment was used in every case. 90.4% of patients with B-linear ALL and 94.1% of T-linear ALL patients had remission. 70.4% of patients with B-linear ALL and 52.9% of those with T-linear ALL are now alive. The presence of unrelated myeloid-associated CD-AGs on B-linear blasts can serve as a positive prognostic sign. My+-B-linear ALL patients are characterised by higher survival. CD34 on blast cells is a positive prognostic sign in patients with B-linear ALL and a negative sign in those with T-linear ALL. The completeness of the representation of the main AGs characteristic of B-linear blast cells as well as the level of their expression were inversely correlated with the initial leukocytosis. CD4+CD8+ was shown to be the worst variant of the T-linear ALL. The development of other treatment programs is required for such patients.

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