TISSUE DISTRIBUTION OF POLYBUTYLCYANOACRYLATE NANOPARTICLES IN EHRLICH ASCITES TUMOR-BEARING MICE

Simeonova M., Ivanova T.

The aim of the present study was to evaluate the tissue distribution of polybutylcyanoacrylate nanoparticles (PBCN) in albino H mice bearing Ehrlich ascites tumor (EAT). Tissue accumulation of nanoparticles in liver, lung, spleen, and kidneys, as well as in brain and blood was evaluated. The study was based on the electron-spin resonance (ESR) measurement of tissue concentration of spin-labelled nitrosourea (SLCNU) used as a spin label for diamagnetic PBCN. Three days after inoculation mice were given i.p. 1 ml of spin labelled suspension of nanoparticles with mean diameter of 125 ± 15 nm. SLCNU-PBCN were accumulated mainly in the spleen, lung, kidneys and in a lesser degree in the liver. The brain accumulation was scarce while in the blood samples only traces of ESR-signals were detected 15 min following i.p. injection. The paper provides evidence that normal and tumor-bearing mice differ in tissue distribution of SLCNU-PBCN.

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