CHANGED ANTITUMOR RESISTANCE AS A GENETIC CONSEQUENCE OF PROLONGED EXPOSURE TO SPECTRUM OF RADIONUCLIDES OF CHERNOBYL DISCHARGE

Savtsova Z.D., Voyejkova I.M., Indyk V.M., Dzhaman N.I., Yudina O.Y., Kovbasiuk S.A., Zaritskaya M.Y.

Summary. Antitumor resistance was investigated in progeny (F1 –F2 ) of C57Bl males who had been exposed for a long time to irradiation in the Chernobyl NPP zone without exposure of the progeny to above-natural background loads in the embryonic and postnatal periods. Uniform-type changes were found in antitumor resistance to both highly antigenic (B-16 melanoma) and low antigenic (Lewis carcinoma) tumors. The character of changes in antitumor resistance was shown to vary in different generations of exposed animals’ progeny. Depending on the activity of effectors of non-specific antitumor responses, effectors of specific immune cytolysis, and suppressor activity, antitumor resistance to the transplantable model tumors studied was reduced (in F1 ), unchanged or even increased (in F2 ). Our findings suggest that changed antitumor resistance may be reckoned as one of the genetic effects of prolonged exposure of one of the parents (male) to combined irradiation in low doses.

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