SIGNIFICANCE OF EXPRESSION OF CD54, CD25, PROLIFERATING CELL ANTIGENS, AND lgM IN TUMOR CELLS AND LYMPHOCYTES FOR THEIR INTERACTIONS IN VITRO

Berezhnaya N.M., Spivak S.I., Vinnichuk Yu.D., Kovalchuk E.V., Konovalenko V.F.

The role of the expression of proliferating cell antigen, CD54, CD25, and IgM in the interaction of lymphocytes of distant and regional lymph nodes with tumor cells was studied upon analysis of MH-rabdomyosarcoma growth and methylcholanthrene-induced tumorigenesis. Antitumor activity of regional lymph node lymphocytes was higher than antitumor activity of distant lymph node lymphocytes. Such an activity was more pronounced in case of transplantable MH-rabdomyosarcoma. This antitumor activity correlated with expression of CD54 and IgM on lymphocytes of mice with MH-rabdomyosarcoma and with proliferating cell antigen expression on lymphocytes of mice with methylcholanthrene-induced tumors.

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