ANALYTICAL CHEMICAL CONSIDERATIONS ON TUMOR GENESIS

Campanella L.

Summary. The differences in the content of both heavy metals and free radicals in tumors and normal tissue of kidneys have been analyzed. Concentration of free radicals was measured by means of a superoxide dismutase biosensor that has been recently developed in our laboratory. Two main differences were observed: 1) higher metal concentration in normal tissues than in tumor ones; 2) higher concentrations of radicals and toxic agents, as particularly benzene, in tumor tissue with accompanying lower concentrations of radical scavengers. Such differences in radical concentrations can be related to: lowered superoxide dismutase activity in tumor tissue and production of free radicals by means of so named secondary metabolism pathways of some compounds adsorbed from the environment.

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