INFLUENCE OF Pt-DNA-ІІІ ON THE SURVIVAL OF CULTURED CELLS OF HUMAN BRAIN TUMORS

Glavatsky O.Ya., Volchenskova I.I., Semenova V.M., Hmelnitsky G.V., Shalimov S.O., Maidanevich N.M., Staino L.P.

The influence of different doses of the platinum derivative Pt-DNA-ІІІ on the survival of cultured cells obtained from brain tumors of 13 operated patients was investigated. The treatment of cell cultures for 24 h with Pt-DNA-ІІІ at the increasing doses from 7.5 to 30 мg/ml resulted in the monotonous decrease of the cell survival. At the highest dose of the drug the inhibition of cell reproduction (70–90%) was observed.

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