INFLUENCE OF MYELOPEPTIDE-2 ON TUMOR GROWTH AND INTERACTION BETWEEN TUMOR CELLS AND LYMPHOCYTES IN VITRO

Berezhnaya N.M., Vinnichyk U.D., Spivak S.I., Tolstopyatov B.A., Kovalchyk E.V.

Effects of different doses of myelopeptide-2 (MP-2) (0.1; 1 and 50 mg/ml) on tumor cell growth and interaction between tumor cells and lymphocytes in vitro were studied. Tumor cells and lymphocytes from distant and regional lymph nodes of C57BL/6 mice bearing B16 melanoma as well as tumor cells and autologic peripheral blood lymphocytes of patients with malignant melanoma have been investigated. The most pronounced inhibition of the growth of B16 melanoma and human malignant melanoma cells was evident at MP-2 dose of 50 mg/ml. The same dose of MP-2 was also shown to increase the inhibition of B16 melanoma cell growth caused by regional and distant lymph node lymphocytes of mice. MP-2 doses 0.1 and 1 mg/ml increased antitumor activity of regional lymph node lymphocytes, while the dose 1 mg/ml increased also antitumor activity of distant lymph node lymphocytes of mice bearing B16 melanoma. However, at the same doses no increase of inhibitory effect of human donor and intact mice lymphocytes was detected. MP-2 at all the doses under study (0.1; 1 and 50 mg/ml) increased inhibitory effect of peripheral blood lymphocytes from patients with melanoma towards autologic malignant melanoma cells.

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