EFFECT OF COMPLEX CONTAINING ANTIOXIDANTS AND ENTEROSORBENT ON NEPHRO- AND UROTOXICITY OF CYCLOPHOSPHAMIDE AND EXCRETION OF ITS METABOLITES WITH URINE IN RATS WITH GUERIN’S CARCINOMA

Kakarkin А.J., Pentyuk A.A., Pushkar M.S., Kakarkinа L.I.

Cyclophosphamide treatment at therapeutic doses resulted in the injury of kidney and urinary tract in rats with accompanying edema of the bladder and renal papillae, decrease in the diuresis and glomerular filtration as well as increasing gamma-glutamiltransferase activity in urine, proteinuria, dystrophy and leukocyte infiltration of bladder mucous membrane, dystrophy and necrosis of the epithelial cells of the proximal convoluted tubules. The manifestations of the nephro- and urotoxicity closely correlated with urine levels of acrolein, mercapturate and in some extent with urine levels of alkylating and non-alkylating metabolites. The antioxidants in the combination with enterosorbent protected the urinary tract against the cyclophosphamide-induced damage with decreasing generation of urotoxic metabolites.

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