PATTERN OF b-DEFENSIN-2 (hBD-2) AND EGFR mRNAs EXPRESSION IN CERVICAL AND VULVAE CANCER CELLS

Vinnitskaya A.B.1, Soldatkina M.A.2, Lisovskiy I.L., Lytvyn D.I., Markeeva N.V.3, Turchak O.V.1, Nespryadko S.V.4, Nosach L.N.5, Povnitsa O.U.6, Pogrebnoy P.V.2

Summary. The present work continues the study of b-defensin gene expression in malignantly transformed human cells of genital origin. We have shown that in A431 and M-HeLa cells the hBD-2 mRNA expression may be induced by either EGF or bacterial (but not viral) stimulation and is stable for at least 12 h. It was shown also that 24-h long challenge of A431 cells with LPS, bacteria or EGF caused significant decrease of the level of EGFr autophosphorylation and didn’t affect the level of expression of EGFr mRNA. The research of surgical specimens has shown that the expression of hBD-2 mRNA and overexpression of EGFr mRNA are typical only for tumor cells of cervix and vulvae, but not for normal ones, and those patterns are associated with the presence of papillomavirus infection.

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