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LOCAL IRRADIATION OF PRIMARY TUMOR DIMINISHES DEVELOPMENT OF LEUCOCYTOSIS AND METASTASIS IN MICE WITH LEWIS LUNG CARCINOMA
Progressive growth of Lewis lung carcinoma in C57Bl/6 mice resulted in a marked leukocytosis, increased serum level of granulocyte/macrophage-colony-stimulating factor, and splenomegaly. The heightened myeloid response was significantly correlated with tumor’s volume increasing rate at the second week after tumor cells inoculation. During this period, local gamma-irradiation of primary tumor (two or five fractions, each fraction of 10 Gy) has induced the retardation of tumor growth, and leucocytosis in tumor-bearing mice was diminished. Prominent reduction in lung metastasis was revealed. Reduction of the tumor-induced myelopoiesis stimulation and associated immunosuppressive activity are suggested as possible mechanisms of the metastasis level decrease.
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