FLOW CYTOMETRY ANALYSIS OF DENDRITIC CELL SURFACE ANTIGENS IN THE DIFFERENT WAYS OF EL-4 LYMPHOMA CELL ADMINISTRATION

Sevko A.L., Shurinsup M.R.

There have been shown that the inhibition of bone marrow derived dendritic cells (DC) differentiation was dependent on the way of the tumor cell administration for recipient animals in our investigation. The strongest suppression of DC differentiation is observed in intravenous administration of EL-4 lymphoma cells. Thus, there was twice lower expression of the IAb, CD86, CD80, CD40, CD11b and CD11c on the surface of the cultured bone marrow derived dendritic cells in intravenous administration of lymphoma cells as compared with control. CD40 and CD86 expression was shown to increase significantly upon subcutaneous and intraperitoneal EL-4 lymphoma cells transplantation.

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